APExBIO - TOK-001|CYP17 inhibitor and androgen receptor (AR) antagonist|CAS# 851983-85-2
Frontiers | Second-Generation Antiandrogens: From Discovery to Standard of Care in Castration Resistant Prostate Cancer
CYP17 inhibitors—abiraterone, C17,20-lyase inhibitors and multi-targeting agents | Nature Reviews Urology
Emerging mechanisms of resistance to androgen receptor inhibitors in prostate cancer | Nature Reviews Cancer
An electron transfer competent structural ensemble of membrane-bound cytochrome P450 1A1 and cytochrome P450 oxidoreductase | Communications Biology
Neoadjuvant hormonal therapy before radical prostatectomy in high-risk prostate cancer | Nature Reviews Urology
Drug discovery in advanced prostate cancer: translating biology into therapy | Nature Reviews Drug Discovery
Promising Tools in Prostate Cancer Research: Selective Non-Steroidal Cytochrome P450 17A1 Inhibitors | Scientific Reports
Computation | Free Full-Text | Exploring the Chemical Space of Cytochrome P450 Inhibitors Using Integrated Physicochemical Parameters, Drug Efficiency Metrics and Decision Tree Models
Targeting of CYP17A1 Lyase by VT-464 Inhibits Adrenal and Intratumoral Androgen Biosynthesis and Tumor Growth of Castration Resistant Prostate Cancer | Scientific Reports
CYP17 inhibitors for prostate cancer therapy - ScienceDirect
Pharmaceuticals | Free Full-Text | Mechanism of the Dual Activities of Human CYP17A1 and Binding to Anti-Prostate Cancer Drug Abiraterone Revealed by a Novel V366M Mutation Causing 17,20 Lyase Deficiency
Resistance to second-generation androgen receptor antagonists in prostate cancer | Nature Reviews Urology
CYP17 inhibitors for prostate cancer therapy - ScienceDirect
APExBIO - Abiraterone|Potent CYP17 inhibitor|CAS# 154229-19-3
Androgen-targeted therapy in men with prostate cancer: evolving practice and future considerations | Prostate Cancer and Prostatic Diseases
Biased cytochrome P450-mediated metabolism via small-molecule ligands binding P450 oxidoreductase | Nature Communications
Targeting signaling pathways in prostate cancer: mechanisms and clinical trials | Signal Transduction and Targeted Therapy
ARe we there yet? Understanding androgen receptor signaling in breast cancer | npj Breast Cancer
Effect of Natural Polyphenols on CYP Metabolism: Implications for Diseases | Chemical Research in Toxicology
Mechanisms of resistance to CYP17 inhibitors. Androgen receptor (AR)... | Download Scientific Diagram
Targeting signaling pathways in prostate cancer: mechanisms and clinical trials | Signal Transduction and Targeted Therapy
Mechanisms of resistance to CYP17 inhibitors. Androgen receptor (AR)... | Download Scientific Diagram
CYP17 inhibitors in prostate cancer: latest evidence and clinical potential - Anitha B. Alex, Sumanta K. Pal, Neeraj Agarwal, 2016
